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selected publications
- Hoyal, C. R., Gutierrez, A., Young, B. M., Catz, S. D., Liu, J. H., Tsichlis, P. N., and Babior, B. M. 2003. Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase. Proc. Natl. Acad. Sci. USA 100: 5130-5135. [ view abstract ]
- Grille, S. J., Bellacosa, A., Upson, J., Klein, Szanto, A. J., van Roy, F., Lee-Kwon, W., Donowitz, M., Tsichlis, P. N., and Larue, L. 2003. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res. 63: 2172-2178. [ view abstract ]
- Eliopoulos, A. G., Wang, C. C., Dumitru, C. D., and Tsichlis, P. N. 2003. Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40. EMBO J. 22: 3855-3864. [ view abstract ]
- Doan, L. L., Kitay, M. K., Yu, Q., Singer, A., Herblot, S., Hoang, T., Bear, S. E., Morse III, H. C., Tsichlis, P. N., and Grimes, H. L. 2003. Growth factor independence-1B expression leads to defects in T cell activation, IL-7 receptor a expression, and T cell lineage commitment. J. Immunol. 170: 2356-2366. [ view abstract ]
- Kontoyiannis, D., Boulougouris, G., Manoloukos, M., Armaka, M., Apostolaki, M., Pizarro, T., Kotlyarov, A., Forster, I., Flavell, R., Gaestel, M., Tsichlis, P., Cominelli, F., and Kollias, G. 2002. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J. Exp. Med. 196:1563-1574. [ view abstract ]
- Eliopoulos, A. G., Dumitru, C. D., Wang, C. C., Cho, J., and Tsichlis, P. N. 2002. Induction of COX-2 by LPS in macrophasges is regulated by Tpl2-dependent CREB activation signals. EMBO J. 21: 4831-4840. [ view abstract ]
- Basso, A. D., Solit, D. B., Chiosis, G., Giri, B., Tsichlis, P., and Rosen, N. 2002. Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J. Biol. Chem. 277: 39858-39866. [ view abstract ]
- Zhu, J., Guo, L., Min, B., Watson, C. J., Hu-Li, J., Young, H. A., Tsichlis, P. N., and Paul, W. E. 2002 Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity 16: 733-744. [ view abstract ]
- Chan, T. O., Rodeck, U., Chan, A. M., Kimmelman, A. C., Rittenhouse, S. E., Panayotou, G., and Tsichlis, P. N. 2002. Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit. Cancer Cell 1: 181-191. [ view abstract ]
- Malstrom, S., Tili, E. Kappes, D., Ceci, J. D., and Tsichlis, P. N. 2001. Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus. Proc. Natl. Acad. Sci. USA 98: 14967-14972. [ view abstract ]
- Pekarsky, Y., Koval, A., Hallas, C., Bichi, R., Tresini, M., Malstrom, S., Russo, G., Tsichlis, P., and Croce, C. M. 2000. Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. Proc. Natl. Acad. Sci. USA 97:3028-3033. [ view abstract ]
- Dumitru, C. D., Ceci, J. D., Tsatsanis, C., Kontoyiannis, D., Stamatakis, K., Lin, J. H., Patriotis, C., Jenkins, N. A., Copeland, N. G., Kollias, G., Tsichlis, P. N. 2000. TNF-α induction by LPS is regulated posttrascriptionally via a Tpl2/ERK-dependent pathway. Cell 103: 1071-1083. [ view abstract ]
- Franke, T. F., Yang, S. -I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan. D. R., Tsichlis, P. N. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of platelet-derived growth factor (PDGF)-activated phosphatidylinositol 3-kinase (PI 3-kinase). Cell 81: 727-736. [ view abstract ]
- Gilks, C. B., Bear, S. E., Grimes, H. L., and Tsichlis, P. N. 1993. Progression of interleukin-2 (IL-2) dependent rat T cell lymphoma lines to IL-2 independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein. Mol. Cell. Biol. 13: 1759-1768. [ view abstract ]
- Patriotis, C., Makris, A., Bear, S. E., and Tsichlis, P. N. 1993. Tumor progression locus-2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T cell lymphomas and in T cell activation. Proc. Natl. Acad. Sci. USA 90: 2251-2255. [ view abstract ]
- Bellacosa, A., Testa, J., Staal, S., and Tsichlis, P. N. 1991. A retroviral oncogene, Akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254: 274-277. [ view abstract ]
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