The Kuperwasser Laboratory focuses on understanding the various aspects of normal and carcinogenic breast development, with the emphasis on stromal-epithelial interactions involved during progression and metastasis. We have developed and are utilizing various novel human breast xenograft model systems as well as complementary in vitro co-cultures and 3D culture systems to identify molecular pathways that mediate the complex interactions during the various aspects of normal and neoplastic breast development.

Our research focuses on the role of the host in cancer development and progression. We are working toward identifying and understanding how normal breast stem cells, as well as breast cancer stem cells interact with the host cells during cancer formation, expansion and metastasis.