The Role of Protease-Activated Receptors in Vascular Biology and Inflammation

Thrombosis associated with the pathophysiological activation of platelets and vascular cells has brought thrombin and its receptors to the forefront of cardiovascular medicine. Protease signaling through the protease-activated receptors (PARs) has been shown to influence a wide range of physiological responses including platelet activation, intimal hyperplasia, inflammation, and maintenance of vascular tone and barrier function.

Protease-Activated Receptors in Cancer and the Role of Angiogenesis Factors in PAR-Dependent Tumor Cell Biology

In addition to its well-recognized roles in vascular biology and thrombosis, PAR1 has been proposed to be involved in the invasive and metastatic processes of solid tumors and has been identified as an oncogene and an invasogenic factor. Our group has a particular interest in studying the role of the protease-activated receptors in the malignant progression of breast, lung, and other cancers.

Development of Pepducins as Novel Cell-Penetrating Intracellular Agonists and Antagonists of G Protein-Coupled Receptors

We have established a new technology based on cell-penetrating peptides known as pepducins as a novel approach of activating or inhibiting signaling between selected receptors and G proteins. These cell-penetrating pepducins are powerful tools to evaluate PARs, chemokines, and other receptors as potential therapeutic targets in both in vitro and mouse model systems.

Current Openings: We are currently hiring for each of the following research areas:
Cardiovacular Biology (1)
Pepducin Pharmacology (1)
Tumor Biology and Angiogenesis (1)

Interested candidates should forward their CV and cover letter to Dr. Athan Kuliopulos or Dr. Lidija Covic.