selected publications

• Covic, L., Gresser, A. L., Talavera, J., Swift, S., & Kuliopulos, A. (2002) Proc. Natl. Acad. Sci. USA 99, 643-648. Activation and Inhibition of G Protein-coupled Receptors by Cell-Penetrating, Membrane-Tethered Peptides.
  
  

• Covic, L., Misra, M., Badar, J., Singh, C., & Kuliopulos, A. (2002) Nature Medicine 8, 1161-1165. Pepducin-Based Intervention of Thrombin Receptor Signaling and Systemic Platelet Activation.
  
  
• Seeley, S., Covic, L., S. J. Jacques, Sudmeier, J., Baleja, J. and Kuliopulos, A. (2003) Chem. and Biol. 10, 1033-1041. Structural Basis for Thrombin activation of a Tethered Ligand Receptor: Inhibition of Intramolecular Liganding.
  
  
• Boire, A., Covic, L., Agarwal A., Jacques, S., Sherifi S. and Kuliopulos, A. (2005) Cell 120, 303-313, PAR1 is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells.
  
  
• Kaneider, N. C., Agarwal, A., Leger, A. & Kuliopulos, A. (2005) Nature Medicine 11, 661-665. Reversing Systemic Inflammatory Response Syndrome with Chemokine Receptor Pepducins.
  
  
• Leger, A. J., Jacques, S. L., Badar, J., Kaneider, N. C., Derian, C. K., Andrade-Gordon, P., Covic, L. and Kuliopulos, A. (2006) Circulation (in press). Blocking the Protease-Activated Receptor 1-4 Heterodimer in Platelet-Mediated Thrombosis.
  
  
• Kaneider, N.C., Ledger, A.J., Agarwal, A., Nguyen, N., Perides, G., Derian, C., Covic., L., Kuliopulos, A. (2007) Nature Immunology (in press). A Role Reversal for PAR1 in Sepsis-induced Vascular Damage.
  
  
• Nguyen, N., Kuliopulos, A., Graham, R.A., Covic, L. (2006) Cancer Res. 66, 2658-65. Tumor-derived Cyr61(CCN1) promotes stromal matrix metalloproeinase-1 production and protease-activated receptor 1-dependent migration of breast cancer cells.