selected publications

•    Covic, L., Gresser, A. L., Talavera, J., Swift, S., & Kuliopulos, A. (2002) Proc. Natl. Acad. Sci. USA 99, 643-648. Activation and Inhibition of G Protein-coupled Receptors by Cell-Penetrating, Membrane-Tethered Peptides.

•    Covic, L., Misra, M., Badar, J., Singh, C., & Kuliopulos, A. (2002) Nature Medicine 8, 1161-1165. Pepducin-Based Intervention of Thrombin Receptor Signaling and Systemic Platelet Activation.

•    Seeley, S., Covic, L., S. J. Jacques, Sudmeier, J., Baleja, J. and Kuliopulos, A. (2003) Chem. and Biol. 10, 1033-1041. Structural Basis for Thrombin activation of a Tethered Ligand Receptor: Inhibition of Intramolecular Liganding.

•    Boire, A., Covic, L., Agarwal A., Jacques, S., Sherifi S. and Kuliopulos, A. (2005) Cell 120, 303-313, PAR1 is a Matrix Metalloprotease-1 Receptor that Promotes Invasion and Tumorigenesis of Breast Cancer Cells.

•    Kaneider, N. C., Agarwal, A., Leger, A. & Kuliopulos, A. (2005) Nature Medicine 11, 661-665. Reversing Systemic Inflammatory Response Syndrome with Chemokine Receptor Pepducins.

•    Leger, A. J., Jacques, S. L., Badar, J., Kaneider, N. C., Derian, C. K., Andrade-Gordon, P., Covic, L. and Kuliopulos, A. (2006) Circulation 113(9):1244-54. Blocking the Protease-Activated Receptor 1-4 Heterodimer in Platelet-Mediated Thrombosis.

•    Nguyen, N., Kuliopulos, A., Graham, R.A., Covic, L. (2006) Cancer Research 66, 2658-65. Tumor-derived Cyr61 (CCN1) promotes stromal matrix metalloproeinase-1 production and protease-activated receptor 1-dependent migration of breast cancer cells.

•     Kaneider, N.C., Ledger, A.J., Agarwal, A., Nguyen, N., Perides, G., Derian, C., Covic., L., Kuliopulos, A. (2007) Nature Immunology 2007 Dec;8(12) :1303-12. 'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage.

•     Agarwal, A., Covic, L., Sevigny, L. M., Kaneider, N. C., Lazarides, K., Azabdaftari, G., Sharifi S., and Kuliopulos, A. (2008) Mol Can Therap 7:2746-57. Targeting a Metalloprotease-PAR1 Signaling System with Cell-Penetrating Pepducins Inhibits Angiogenesis, Ascites and Progression of Ovarian Cancer.

•     Yang, E., Boire, A., Agarwal, A., Nguyen, N., Kuliopulos, A., and Covic, L. (2009) Cancer Research 69:6223-31. Blockade of metalloprotease-PAR1 signaling with cell-penetrating pepducins inhibits Akt-survival pathways in breast cancer and accelerates tumor death.

•     Trivedi, V., Boire, A., Tchernychev, B., Kaneider, N.C., Leger, A.J., O’Callaghan, K., Covic, L. & Kuliopulos, A. (2009) Cell 137:332-343. Platelet Matrix Metalloprotease-1 Mediates Thrombogenesis by Activating PAR1 at a Cryptic Ligand Site.