My laboratory studies the biological and molecular processes driving Central Nervous System malignancies focusing primarily on Glioblastoma, one of the most devastating cancers. Understanding of the biological and genetic determinants of this malignancy will no doubt result in major clinical advances.

One of our major research programs is the development and testing of targeted therapeutics in genetically modified mouse models of glioblastoma which are based on gene mutations found in human tumors. In addition, we focus on key basic research questions including functional elucidation of specific gene mutations in the tumorigenic program of glioblastomas and to determine how the cellular context in which the mutations occur influences the outcome of these genetic lesions.